List of Pubmed Papers

PUBLICATIONS (from 2010)


  • Hamamura, K., Chen, A., Tanjung, N., Takigawa, S., Sudo, A., Yokota, H. In vitro and in silico analysis of an inhibitory mechanism of osteoclastogenesis by salubrinal and guanabenz. Cellular Signaling (in press).
  • Wan, Q., Xu, W., Yan, J., Yokota, H., Na, S. (2014). Distinctive subcellular inhibition of cytokine-induced Src by salubrinal and fluid flow. PLosOne 9:e105699.
  • Hamamura, K., Chen, A., Nishimura, A., Tanjung, N., Sudo, A., Yokota, H. (2014). Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis.  Cellular Signaling 26:2358-2369.
  • Hamamura, K., Minami, K., Tanjung, N., Wan, Q., Koizumi, M., Matsuura, N., Na, S., Yokota, H. (2014). Attenuation of malignant phenotypes of breast cancer cells through eIF2a-mediated downregulation of Rac1 signaling. Int. J. Oncology 44:1980-1988.
  • Shim, J.W., Dodge, T.R., Hammond, M.A., Wallace, J.M., Zhou, F.C., Yokota, H. (2014). Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PLosOne 9(1):e85095.
  • Zhao, L., Dodge, T., Nemani, A., Yokota, H. (2014). Resonance in the mouse tibia as a predictor of frequencies and locations of loading-induced bone formation. Biomechanics and Modeling in Mechanobiology 13:141-151.


  • Hamamura, K., Chen, A., Tanjung, N., Sun, H.B., Yokota, H. (2013). In vitro and in silico analysis of ADAMTS5 transcription in human chondrocytes. J. Arthritis 2:1000111.
  • Hamamura, K., Zhang, P., Zhao, L., Shim, J.W., Chen, A., Dodge, T.R., Wan, Q., Shih, H., Na, S., Lin, C.C., Sun, H.B., Yokota, H. (2013). Knee loading reduces MMP13 activity in the mouse cartilage. BMC Musculoskeletal Disorders 14:312.
  • Chen, A.B., Zhang, P., Yokota, H. (2013). Evaluating treatment of osteoporosis using particle swarm on a bone remodeling mathematical model. IET Systems Biol. 7:231-242.
  • Rhodes, S.D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K.W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R., Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad, K.S., Xu, M., Guise, T.A., Yang, F.-C. (2013). Hyperactive transforming growth factor b1 signaling potentiates skeletal defects in a neurofibromatosis type I mouse model. J. Bone Miner. Res. 28:2476-2489.
  • Yokota, H., Hamamura, K., Chen, A., Dodge, T.R., Tanjung, N., Abedinpoor, A., Zhang, P. (2013). Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells. BMC Musculoskeletal Disorders 14:197.
  • Shim, J.W., Hamamura, K., Chen, A., Wan, Q., Na, S., Yokota, H. (2013). Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor beta in cartilage and chondrocytes. J. of Musculoskeletal and Neuronal Interactions 13:372-379.
  • Fitzwater, D., Dodge, T., Chien, S., Yokota, H., Anwar, S. (2013). Development of a portable knee rehabilitation device that uses mechanical loading. ASME J. Medical Devices 7:P410071-4100710.
  • Wan, Q., Cho, E., Yokota, H., Na, S. (2013). Rac1 and Cdc42 GTPases regulate shear stress-driven b-catenin signaling in osteoblasts. Biochem. Biophys. Res. Comm. 433:502-507.
  • Hamamura, K., Tanjung, N., Yokota, H. (2013). Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha. J. Bone Miner. Metab. 31:618-628.
  • Wan, Q., Cho, E., Yokota, H., Na, S. (2013). RhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblasts. J. Bone Miner. Metab. 31:520-532.
  • Hamamura, K., Lin, C.C., Yokota, H. (2013). Salubrinal reduces expression and activity of MMP13 in chondrocytes. Osteoarthritis and Cartilage 21:764-772.
  • Wan, Q., Kim, S., Yokota, H., Na, S. (2013). Differential activation of inhibition of RhoA by fluid flow induced shear stress in chondrocytes.  Cell Biol. Intl. 37:568-576.
  • Zhao, L., Shim, J.W., Dodge, T.R., Robling, A., Yokota, H. (2013). Inactivation of Lrp5 in osteocytes reduces Young’s modulus and responsiveness to the mechanical loading. Bone 54:35-43.


  • Yokota, H., Tovar, A., Robling, A. (2012). Dynamic muscle loading and mechanotransduction. Bone 51:826-827.
  • Dodge, T., Wanis, M., Ayoub, R., Zhao, L., Watts, N.B., Bhattacharya, A., Akkus, O., Robling, A., Yokota, H. (2012). Mechanical loading, damping, and load-driven bone formation in mouse tibiae. Bone 51:810-818.
  • Zhang, P., Jiang, C., Yokota, H. (2012). Lengthening of mouse hindlimbs with local administration of insulin-like growth factor 2. J. Chin. Med. Assoc. 75:494-500.
  • Blair, M., Wanis, M., Swarnkar, G., Yokota, H., Chien, S. (2012). Voltage profile generation for simultaneous multi-protein detection in Western blot analysis. J. Biomed. Sci. Eng. 5:542-547.
  • Koizumi, M., Tanjung, N.G., Chen, A., Dynlacht, J.R., Garrett, J., Yoshioka, Y., Ogawa, K., Teshima, T., Yokota, H. (2012). Administration of salubrinal enhances radiation induced cell death of SW1353 chondrosarcoma cells. Anticancer Res. 32:3667-3674.
  • Zhao, L., Tanjung, N., Swarnkar, G., Ledet, E., Yokota, H. (2012). Regulation of eIF2 phosphorylation in hindlimb-unloaded and STS-135 space-flown mice. Adv. Space Res. 50:576-583.
  • Zhang, P., Hamamura, K., Jiang, C., Zhao, L., Yokota, H. (2012). Salubrinal promotes wound healing in rat femurs. J. Bone Miner. Metab. 30:568-579.
  • Hamamura, K., Swarnkar, G., Tanjung, N., Cho, E., Li, J., Na, S., Yokota, H. (2012). RhoA-mediated signaling in mechanotransduction of osteoblasts. Connective Tissue Res. 53:398-406.
  • Hamamura, K., Zhao, L., Jiang, C., Tanjung, N., Swarnkar, G., Yokota, H. (2012). Hydroxyapatite modulates mRNA expression profiles in cultured osteocytes.  Cell. Mol. Bioeng. 5:217-226.
  • Raposo, J.F., Pires, A., Yokota, H., Ferreira, H.G. (2012). A mathematical model of calcium and phosphorus metabolism in two forms of hyperparathyroidism. Endocrine 41:309-319.


  • Sun, H., Zhao, L., Tanaka, S., Yokota, H. (2011). Moderate joint loading reduces degenerative actions of matrix metalloproteinases in the articular cartilage of mouse ulnae. Connective Tissue Res. 53:180-186.
  • Zhao, L., Dodge, T., Ledet, E., Yokota, H. (2011). Knee loading stimulates bone formation in tail-suspended mouse hindlimb. Biol. Sci. Space 25:77-82.
  • Yokota, H., Leong, D.J., Sun, H.B. (2011). Mechanical loading: bone remodeling and cartilage maintenance. Current Osteoporosis Res. 9:237-242.
  • Zhang, P., Yokota, H. (2011). Knee loading stimulates healing of mouse bone wound in a femur neck. Bone 49:867-872.
  • Zhang, P., Yokota, H. (2012). Elbow loading promotes longitudinal bone growth of the ulna and the humerus. J. Bone Miner. Metab. 30:31-39.
  • Zhang, P., Jiang, C., Ledet, E., Yokota, H. (2011). Loading- and unloading-driven regulation of phosphorylation of eIF2a. Biol. Sci. Space 25:3-6.
  • Chen, A., Zhang, P., Duan, Z., Wang, G., Yokota, H. (2011). Modeling the molecular transportation of subcutaneously injected salubrinal. Biomed. Eng. Comp. Biol. 3:1-8.
  • Sun, H.B., Cardoso, L., Yokota, H. (2011). Mechanical intervention for maintenance of cartilage and bone. Clinical Med. Insights: Arthritis and Musculoskeletal Disorders 4:1-6.
  • Zhou, H., Nwnum, A.B., Maritn, J.R., Li, P., Nelson, M.T., Moh, A., Fu, X.Y., Yokota, H., Li, J. (2011). Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species. Bone 49:404-411.


  • Hagyousif, A.M., Chong, V.J., Yokota, H., Chien, S.Y.P. (2010). Development of a novel protein multi-blotting device. J. Biomed. Sci. Eng. 3:1125-1132.
  • Hamamura, K., Jiang, C., Yokota, H. (2010).  ECM-dependent mRNA expression profiles and phosphorylation patterns of p130Cas, FAK, ERK, and p38 MAPK of osteoblast-like cells.  Cell. Biol. Intl. 34:1005-1012.
  • Yokota, H., Pires, A., Raposo, J.F., and Ferreira, H.G. (2010). Model-based analysis of FGF23 regulation in chronic kidney disease. Gene Regulation and Systems Biol.4:53-60.
  • Zhang, P., Liang, Y., Kim, H., Yokota, H. (2010). Evaluation of a pig femoral head osteonecrosis model. J. Ortho. Surg. Res. 5 (15):1-7.
  • Hirasawa, H., Jiang, C., Zhang, P., Yang, F.C., Yokota, H. (2010). Mechanical stimulation suppresses phosphorylation of eIF2a and PERK-mediated responses to stress to the endoplasmic reticulum.  FEBS lett. 584:745-752.
  • Zhang, P., Hamamura, K., Turner, C., Yokota, H. (2010). Lengthening of mouse hindlimb with joint loading.  J. Bone Miner. Metab. 28:268-275.